https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7607 Wed 11 Apr 2018 15:15:09 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9164 Wed 11 Apr 2018 11:29:56 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42975 Tue 20 Aug 2024 12:31:21 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42286 Tue 20 Aug 2024 12:26:40 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39881 Tue 04 Oct 2022 15:37:28 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44701 Thu 20 Oct 2022 15:58:29 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40388 Thu 14 Jul 2022 11:42:24 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8356 Sat 24 Mar 2018 08:39:51 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:11723 Sat 24 Mar 2018 08:07:24 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17463 5 yr postdiagnosis on physical functioning.Design, setting, and participants. Between 2010 and 2011, 100 long-term PCa survivors from Trans-Tasman Radiation Oncology Group 03.04 Randomised Androgen Deprivation and Radiotherapy previously treated with androgen-deprivation therapy and radiation therapy were randomly assigned to 6 mo of supervised exercise followed by 6 mo of a home-based maintenance programme (n = 50) or printed educational material about physical activity (n = 50) for 12 mo across 13 university-affiliated exercise clinics in Australia and New Zealand. Intervention: Supervised resistance and aerobic exercise or printed educational material about physical activity. Outcome measurements and statistical analysis: The primary end point was a 400-m walk as a measure of cardiovascular fitness. Secondary end points were physical function, patient-reported outcomes, muscle strength, body composition, and biomarkers. Analysis of covariance was used to compare outcomes for groups at 6 and 12 mo adjusted for baseline values. Results and limitations: Participants undergoing supervised exercise showed improvement in cardiorespiratory fitness performance at 6 mo (−19 s [p = 0.029]) and 12 mo (−13 s [p = 0.028]) and better lower-body physical function across the 12-mo period (p < 0.01). Supervised exercise also improved self-reported physical functioning at 6 (p = .006) and 12 mo (p = 0.002), appendicular skeletal muscle at 6 mo (p = 0.019), and objective measures of muscle strength at 6 and 12 mo (p < 0.050). Limitations included the restricted number of participants undertaking body composition assessment, no blinding to group assignment for physical functioning measures, and inclusion of well-functioning individuals. Conclusions: Supervised exercise training in long-term PCa survivors is more effective than physical activity educational material for increasing cardiorespiratory fitness, physical function, muscle strength, and self-reported physical functioning at 6 mo. Importantly, these benefits were maintained in the long term with a home-based programme with follow-up at 12 mo. Clinical trial registry: The effect of an exercise intervention on cardiovascular and metabolic risk factors in prostate cancer patients from the RADAR study, ACTRN: ACTRN12609000729224.]]> Sat 24 Mar 2018 08:04:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17686 Sat 24 Mar 2018 07:57:43 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21552 p > 0.9) were found between CT and pseudo-CT Hounsfield units for organs of interest. Mean ± standard deviation DSC scores for the atlas-based segmentation of the pelvic bones were 0.79 ± 0.12, 0.70 ± 0.14 for the prostate, 0.64 ± 0.16 for the bladder, and 0.63 ± 0.16 for the rectum. Conclusions: The electron-density atlas method provides the ability to automatically define organs and map realistic electron densities to MRI scans for radiotherapy dose planning and DRR generation. This method provides the necessary tools for MRI-alone treatment planning and adaptive MRI-based prostate radiation therapy.]]> Sat 24 Mar 2018 07:50:23 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52683 Fri 20 Oct 2023 09:51:01 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34907 interaction = -1.3 s, 95% confidence interval [CI] -2.6 to 0.0), whole-body lean mass (ß_interaction = 1194 g, 95% CI 234 to 2153) and ASM mass (ß_interaction = 562 g, 95% CI 49 to 1075), and approached significance for fat mass (ß_interaction = -1107 g, 95% CI -2346 to 132), with greater benefits for men previously on long-term ADT. At 6 months, the intervention effects on chair rise time -1.5 s (95% CI -2.5 to -0.5), whole-body lean mass 824 g (95% CI 8 to 1640), ASM mass 709 g (95% CI 260 to 1158), and fat mass -1377 g (95% CI -2156 to -598) were significant for men previously on long-term ADT, but not for men on short-term ADT. At 12 months, the intervention effects for men on long-term ADT remained significant for the chair rise, with improved performance (-2.0 s, 95% CI -3.0 to -1.0) and increased ASM (537 g, 95% CI 153 to 921). Time on ADT did not moderate the exercise effects on muscle strength, nor did time since ADT cessation moderate any intervention effects. Similarly, testosterone and baseline values of the outcome had negligible moderator effects. Conclusions: Men with PCa previously treated long-term with ADT respond more favourably to exercise in terms of lower body muscle performance and body composition (lean and fat mass, and ASM) than those with short-term ADT exposure. As a result, men who were formerly on long-term androgen suppression regimens should be especially prescribed exercise medicine interventions to alleviate residual treatment-related adverse effects.]]> Fri 01 Apr 2022 09:25:19 AEDT ]]>